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Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models

Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish

Turmeric, obtained from the rhizomes of Curcuma longa, is used in South Asia as a traditional medicine for the
treatment of epilepsy. To date, in vivo studies on the anticonvulsant activity of turmeric have focused on its
principal curcuminoid, curcumin. However, poor absorption and rapid metabolism have limited the therapeutic
application of curcumin in humans. To explore the therapeutic potential of turmeric for epilepsy further,
we analyzed its anticonvulsant activity in a larval zebrafish seizure assay. Initial experiments revealed
that the anticonvulsant activity of turmeric in zebrafish larvae cannot be explained solely by the effects of
curcumin. Zebrafish bioassay-guided fractionation of turmeric identified bisabolene sesquiterpenoids as additional
anticonvulsants that inhibit PTZ-induced seizures in both zebrafish and mice. Here, we present the
first report of the anticonvulsant properties of bisabolene sesquiterpenoids and provide evidence which warrants
further investigation toward the mechanistic understanding of their neuromodulatory activity.

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