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Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)

Authors: Christopher E Ramsden, Daisy Zamora, Sharon Majchrzak-Hong, Keturah R Faurot, Steven K Broste, Robert P Frantz,  John M Davis, , Amit Ringel, Chirayath M Suchindran, Joseph R Hibbeln.

BMJ 2016;353:i1246


Available evidence from randomized controlled trials (conducted by Ancel Keys) shows that replacement of saturated fat in the diet with linoleic acid effectively lowers serum cholesterol but does not support the hypothesis that this translates to a lower risk of death from coronary heart disease or all causes. Findings from the Minnesota Coronary Experiment add to growing evidence that incomplete publication has contributed to overestimation of the benefits of replacing saturated fat with vegetable oils rich in linoleic acid.

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